Synergism in drug use means:

Synergism in drug use refers to the phenomenon where the combined effects of two substances result in a greater effect than the sum of their individual effects. In the context of the correct answer, using alcohol with a prescription medication can significantly enhance the effects or side effects of the medication. This is because both alcohol and many prescription drugs are metabolized by the liver, and their concurrent use can lead to an increased impact on the body, potentially causing heightened impairment or adverse reactions.

This understanding is crucial for recognizing the risks involved in combining substances, emphasizing the importance of being aware of how different substances interact within the body. This awareness is particularly vital in the context of driving and overall health, helping individuals make informed decisions.